Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies

by Nurtop et al.

The authors of this study propose a strategy allowing implementing efficient and practicable large-scale seroepidemiological studies for Zika Virus (ZIKV).

27th December 2018 • comment

Evidence for congenital Zika virus infection from neutralizing antibody titers in maternal sera, north-eastern Brazil

by Moreira-Soto et al.

Results from this study suggest that despite the inter-individual variability in immune responses, the magnitude of the maternal ZIKV-specific neutralizing antibody response may prove useful to corroborate congenital ZIKV infection, contributing to reliable estimates of the manifestation index of ZIKV-associated congenital disease. Further studies will be needed to evaluate the time-course of maternal neutralizing antibody responses to identify whether a high maternal PRNT titer can be used as an early marker of congenital infection aiding potential antiviral intervention strategies.

9th October 2017 • comment